Liver failure acute infantile

Common Name(s)

Liver failure acute infantile

Acute infantile liver failure resulting from TRMU mutation is a transient disorder of hepatic function. In addition to elevated liver enzymes, jaundice, vomiting, coagulopathy, and hyperbilirubinemia, the presence of increased serum lactate is consistent with a defect in mitochondrial respiratory function. With supportive care, patients who survive the initial acute episode can recover and show normal development ({3:Zeharia et al., 2009}). See also transient infantile mitochondrial myopathy (MMIT; {500009}), which is a similar disorder. A more severe, permanent disorder with some overlapping features is associated with mitochondrial DNA depletion ({251880}). See ILFS1 ({615438}) for information on syndromic infantile liver failure.
 

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Condition Specific Organizations

Following organizations serve the condition "Liver failure acute infantile" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver failure acute infantile" returned 1 free, full-text research articles on human participants. First 3 results:

Acute infantile liver failure due to mutations in the TRMU gene.
 

Author(s): Avraham Zeharia, Avraham Shaag, Orit Pappo, Anne-Marie Mager-Heckel, Ann Saada, Marine Beinat, Olga Karicheva, Hanna Mandel, Noa Ofek, Reeval Segel, Daphna Marom, Agnes Rötig, Ivan Tarassov, Orly Elpeleg

Journal: Am. J. Hum. Genet.. 2009 Sep;85(3):401-7.

 

Acute liver failure in infancy accompanied by lactic acidemia was previously shown to result from mtDNA depletion. We report on 13 unrelated infants who presented with acute liver failure and lactic acidemia with normal mtDNA content. Four died during the acute episodes, and the survivors ...

Last Updated: 31 Dec 1969

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The terms "Liver failure acute infantile" returned 0 free, full-text review articles on human participants.

 
 
 
 
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