Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childĂ•s age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3520 free, full-text research articles on human participants. First 3 results:

Intracranial immature teratoma invading the nasal cavity mimicking olfactory neuroblastoma: A case report.
 

Author(s): Yuefeng Jiang, Xiaoyun Mao, Yang Zhao, Chuifeng Fan

Journal: Medicine (Baltimore). 2018 Jul;97(28):e11527.

 

Primary intracranial immature teratoma accounts for majority of congenital central nervous system germ-cell tumors, but it is extremely rare in patients older than 15 years.

Last Updated: 31 Dec 1969

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ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
 

Author(s): Marco Pieraccioli, Sara Nicolai, Consuelo Pitolli, Massimiliano Agostini, Alexey Antonov, Michal Malewicz, Richard A Knight, Giuseppe RaschellĂ , Gerry Melino

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2018 07;115(28):7356-7361.

 

Derangement of cellular differentiation because of mutation or inappropriate expression of specific genes is a common feature in tumors. Here, we show that the expression of ZNF281, a zinc finger factor involved in several cellular processes, decreases during terminal differentiation ...

Last Updated: 31 Dec 1969

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Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry.
 

Author(s): Mohsin El Amrani, Celina L Szanto, C Erik Hack, Alwin D R Huitema, Stefan Nierkens, Erik M van Maarseveen

Journal: Anal Bioanal Chem. 2018 Sep;410(23):5849-5858.

 

Neuroblastoma is one of the most commonly found solid tumors in children. The monoclonal antibody dinutuximab (DNX) targets the sialic acid-containing glycosphingolipid GD2 expressed on almost all neuroblastoma tumor cells and induces cell lysis. However, the expression of GD2 is ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 122 free, full-text review articles on human participants. First 3 results:

Paraneoplastic limbic encephalitis associated with mixed olfactory neuroblastoma and craniopharyngioma: A case report and literature review.
 

Author(s): Hiroshi Nagafuji, Hidenori Yokoi, Masachika Fujiwara, Dai Sato, Koichiro Saito

Journal: Medicine (Baltimore). 2018 Jun;97(24):e10932.

 

Paraneoplastic limbic encephalitis (PLE) is a rare disorder of the nervous system associated with malignant disease. It has a subacute onset with the following symptoms: cognitive dysfunction, seizures, irritability, hallucinations, and short-term memory loss. Herein, we report the ...

Last Updated: 31 Dec 1969

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Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma.
 

Author(s): Thitinee Vanichapol, Somchai Chutipongtanate, Usanarat Anurathapan, Suradej Hongeng

Journal:

 

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood with 5-year survival rate of 40% in high-risk patients despite intensive therapies. Recently, adoptive cell therapy, particularly chimeric antigen receptor (CAR) T cell therapy, represents a revolutionary ...

Last Updated: 31 Dec 1969

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Adult renal neuroblastoma: A case report and literature review.
 

Author(s): Ming-De Huang, Li-Sheng Hsu, Huei-Chieh Chuang, Wei-Yu Lin, Wei-Hsiu Lin, Chih-Wei Yen, Min-Lang Chen

Journal: Medicine (Baltimore). 2018 Apr;97(14):e0345.

 

Adult renal neuroblastoma (NB) is extremely rare, and there have been only a few cases previously described in the literature. We report a case of adult renal NB and summarize the clinical and imaging features of the reported cases.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 16 Aug 2018

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Naxitamab for Neuroblastoma With Osteomedullary Disease
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 13 Sep 2018

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Not yet recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 16 Aug 2018

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