is a rare disease of unknown cause, characterized by overgrowth of mature, non-cancerous fat cells in the pelvic region. The symptoms of pelvic lipomatosis are related to the compression of the urinary system (urinary frequency, dysuria, nocturia, and hematuria), lower intestinal tract (constipation, tenesmus, rectal bleeding, and ribbon-like stools with mucus), and vascular system (edema of lower extremities). Pelvic lipomatosis has been linked to chronic lower urinary tract infections, obesity, and endocrine dysfunction. Treatment usually seeks to alleviate symptoms, especially kidney obstruction and end stage renal disease. While most cases are not progressive, upper-tract urinary surgery may be needed for those with severe symptoms and/or evidence of urinary obstruction with deterioration of the kidney function. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.