Rat-bite fever (RBF) is an infectious disease caused by two types of bacteria: Streptobacillus moniliformis in North America, known as streptobacillary RBF, and Spirillum minus mainly in Asia, known as spirillary RBF. People can get RBF from bites or scratches from infected rodents, handling rodents with the disease, or consuming food or drink contaminated with the bacteria. RBF is not spread from person to person. People who may be at increased risk include those who live in rat-infested buildings, have pet rats, or work with rats in laboratories or pet stores. Symptoms of streptobacillary RBF include fever, vomiting, headache, muscle pain, joint pain, and rash. These symptoms usually occur 3-10 days after exposure to an infected rodent, and within 2-4 days after the onset of fever, a rash with small bumps may appear on the hands and feet. Symptoms of spirillary RBF (also called sodoku) vary but often include fever, development of an ulcer at the bite wound, swelling near the wound, swollen lymph nodes, and a rash. Without treatment, RBF can be serious and potentially fatal.