Resistance to thyroid stimulating hormone (TSH) is a genetic condition that is inherited in an autosomal dominant manner. We inherit our genes in pairs, typically with one from each parent. If a change (mutation) occurs in a gene, it may cause problems. Autosomal dominant means that an individual only needs to inherit one changed gene from either parent to show symptoms.
The thyroid gland is located below the “Adams apple” on the front of the neck. This gland controls hormones called thyroid hormones. Thyroid hormones are very important in controlling how our body regulates energy. This means that the thyroid hormones affect how fast or slow our brain, heart, liver, muscles, and many other tissues and organs function.
Resistance to TSH has a variety of symptoms that depend on the severity of the condition. Some individuals will experience no symptoms whereas others may be more severely affected. Some individuals may experience raised cholesterol levels (cholesterol is a fat molecule in our blood), increased feeling of tiredness, and are often overweight. Children who are affected may have difficulty hearing, slow developmental growth, common ear, nose, and throat infections, and problems paying attention.
Resistance to TSH can typically be diagnosed with a blood test. This will measure the levels of certain thyroid hormones and can be especially helpful in diagnosing the individuals who experience no symptoms. Further testing depends on medical and family history. Many individuals will not require treatment for this condition. Children will frequently visit their doctor to check their growth and development. For more severe cases of TSH resistance, there are medications that an individual can take. If you or a family member has been diagnosed with resistance to thyroid stimulating hormone, talk to your doctor about the most current treatment options.
Description Last Updated: Feb 26, 2018