Talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals is a type of osteolysis, or a disorder that involves bone breakdown. There have only been a few individuals diagnosed with this condition and the first diagnosis occurred in 2003. The age of onset for this condition is the early teenage years, around 11-15 years old. The ankle, wrist, and kneecap are the three main structures that are affected. Main symptoms include ankle and knee pain, a short ring finger, difficulty bending the ankles and wrists backwards, limited foot motion, and joint inflammation and swelling.
It is currently believed that this condition is inherited (passed through families) in an autosomal recessive manner. We inherit our genes in pairs, one from each parent. With autosomal recessive conditions both copies of a gene need to have a change or mutation in order for the condition to occur. The gene responsible is still unknown. If you or a family member has been diagnosed with this condition, talk with your doctor about the most current treatment options. Support groups are also good resources of support and information.
Description Last Updated: Feb 15, 2018