Tay-Sachs disease, late onset is a special form of Tay-Sachs disease in which symptoms do not appear until later in life (Please also see: Tay-Sachs disease). Individuals with late onset Tay-Sachs disease begin to display symptoms between adolescence and their late 30s, while classical Tay-Sachs disease affects infants.
Symptoms of late onset Tay-Sachs disease vary greatly between different individuals, but may include muscle weakness or cramping, lack of coordination, difficulty swallowing, and difficulty walking. Symptoms often get worse with age. Like infantile Tay-Sachs disease, late onset is rare in the general population, but more common among people of Ashkenazi Jewish heritage. There is currently no cure for late onset Tay-Sachs disease, but symptoms can be managed with physical therapy and devices to help support those with difficulty walking.
If you or someone you know has been diagnosed with a late onset form of Tay-Sachs disease, speak with your doctor or genetic counselor to discuss the most current treatment options.