XX male syndrome

Common Name(s)

XX male syndrome

XX male syndrome, also known as de la Chapelle syndrome, is a rare genetic condition. This condition results from a mutation or error in a person’s DNA or genes. This condition causes a person to be male-appearing physically, while also having certain female DNA or genes. This can also cause the affected individual to have small testicles, poor facial hair growth, and other feminine characteristics. People with this condition are also sterile, or unable to have children. XX males occur in 5 out of every 100,000 individuals. Affected individuals are typically raised as males and go on to lead normal healthy lives. Although there is no cure for XX male syndrome, there are various resources to help manage the condition physically, psychologically, and emotionally. Doctors seek help from various therapists and community services to provide support and care for families affected by XX male syndrome.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "XX male syndrome" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "XX male syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "XX male syndrome" returned 7 free, full-text research articles on human participants. First 3 results:

Cytogenic and molecular analyses of 46,XX male syndrome with clinical comparison to other groups with testicular azoospermia of genetic origin.
 

Author(s): Han-Sun Chiang, Yi-No Wu, Chien-Chih Wu, Jiann-Loung Hwang

Journal: J. Formos. Med. Assoc.. 2013 Feb;112(2):72-8.

 

XX male is a rare sex chromosomal disorder in infertile men. The purpose of this study was to distinguish the clinical and genetic features of the 46,XX male syndrome from other more frequent, testicular-origin azoospermic causes of male infertility.

Last Updated: 31 Dec 1969

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Clinical, cytogenetic, and molecular analysis with 46,XX male sex reversal syndrome: case reports.
 

Author(s): Xuefeng Gao, Guian Chen, Jing Huang, Quan Bai, Nan Zhao, Minjie Shao, Liping Jiao, Yanling Wei, Liang Chang, Dan Li, Liping Yang

Journal: J. Assist. Reprod. Genet.. 2013 Mar;30(3):431-5.

 

To investigate the clinical characteristics of different categories of sex-reversed 46,XX individuals and their relationships with chromosomal karyotype and the SRY gene.

Last Updated: 31 Dec 1969

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46, XX male sex reversal syndrome.
 

Author(s): Jian-Hong Li, Tian-Hua Huang, Xue-Wu Jiang, Qing-Dong Xie

Journal: Asian J. Androl.. 2004 Jun;6(2):165-7.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "XX male syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Uterus Transplantation From a Multi-organ Donor
 

Status: Recruiting

Condition Summary: Infertility, Female; Mayer Rokitansky Kuster Hauser Syndrome

 

Last Updated: 16 Aug 2017

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Penn Uterine Transplantation for Uterine Factor Infertility Trial
 

Status: Recruiting

Condition Summary: Mayer Rokitansky Kuster Hauser Syndrome; Uterine Agenesis; Infertility, Female, of Uterine Origin; Uterine Factor Infertility

 

Last Updated: 28 Aug 2018

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Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study
 

Status: Recruiting

Condition Summary: Mayer Rokitansky Kuster Hauser Syndrome; Mullerian Aplasia; Uterus; Absence, Congenital; Infertility, Female; Uterus Absence, Acquired; Absolute Uterine Factor Infertility

 

Last Updated: 12 Sep 2017

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